Table 2.
Nakanuma’s staging system [35]
| Nakanuma’s staging system | |
|---|---|
| SCORING | |
| Score | Fibrosis |
| 0 | No portal fibrosis or fibrosis limited to portal tracts |
| 1 | Portal fibrosis with periportal fibrosis or incomplete septal fibrosis |
| 2 | Bridging fibrosis with variable lobular disarray |
| 3 | Liver cirrhosis with regenerative nodules and extensive fibrosis |
| Bile duct loss | |
| 0 | No bile duct loss |
| 1 | Bile duct loss in < 1/3 of portal tracts |
| 2 | Bile duct loss in 1/3–2/3 of portal tracts |
| 3 | Bile duct loss in > 2/3 of portal tracts |
| Deposition of orcein positive granules | |
| 0 | No deposition of granules |
| 1 | Deposition of granules in several periportal hepatocytes in < 1/3 of portal tracts |
| 2 | Deposition of granules in a variable periportal hepatocytes in 1/3–2/3 of portal tracts |
| 3 | Deposition of granules in many hepatocytes in > 2/3 of portal tracts |
| STAGING | |
| Stage | Sum of score: fibrosis, bile duct loss and deposition of orcein-positive granules |
| 1 (no progression) | 0 |
| 2 (mild progression) | 1–3 |
| 3 (moderate progression) | 4–6 |
| 4 (advanced progression) | 7–9 |
| Sum of score: bile duct loss and fibrosis | |
| 1 (no progression) | 0 |
| 2 (mild progression) | 1–2 |
| 3 (moderate progression) | 3–4 |
| 4 (advanced progression) | 5–6 |