Table 3.

Primary and secondary outcomes of the study

	Paracetamol (n = 52)	Ibuprofen (n = 49)	P
First course of treatment
Closed DA	27 (52)	38 (78)	0.026
Not hsPDA	15 (29)	6 (12)	0.039
Constricted DA (closed or not hsPDA)	42 (81)	44 (90)	0.202
hsPDA	10 (19)	5 (10) a	0.202
	n = 10	n = 5
Second course of treatment with ibuprofenb
Closed DA	4 (40)	2 (50)	0.452
Not hsPDA	3 (30)	2 (50)	0.696
Constricted DA (closed or not hsPDA)	7 (70)	4 (100)	0.216
hsPDA	3 (30)	0 (0)	0.088
Re-opening within 30 days of lifec	14 (36)	8 (19)	0.078
Surgical closure within 30 days of lifec	0	1 (2)	0.338

Data presented as rate (%)

DA ductus arteriosus, hsPDA hemodynamically patent ductus arteriosus

^aOne patient in ibuprofen group was not treated with the second course of treatment as per physician’s decision

^bIn both groups

^cIn infants who had constricted DA (closed + not hsPDA) after the first course of treatment: calculated from available data of 39 patients in paracetamol group and 43 in ibuprofen group