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. 2021 Feb 16;11:3940. doi: 10.1038/s41598-021-83224-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Model of a transmembrane complex between the lateral gate of SecY and the hydrophobic slide of YidC. The SecY TM1-10 (PDB 3J01) is coloured blue, and the YidC TM2-6 (PDB 3WVF) is coloured green. The residues of SecY (G123 and F328) contacting YidC (I432 and P499) are in red. The TM of the lateral gate (SecY-TM2b, 3, 7 and 8, blue arrowhead) interacts with the hydrophobic slide (YidC TM3 and 5, green arrowhead). Therefore, the pore of SecY and the hydrophilic groove of YidC could form an extended cavity for hosting a substrate.