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. 2021 Feb 16;11:3890. doi: 10.1038/s41598-021-82066-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Viral constructs made with patient-derived HIV env from AMs and plasma productively infect MDMs more efficiently through T cell contact. Experimental conditions were as in Fig. 3 with the HIV constructs described in Fig. 2. Cells were infected with AM-derived (A) or plasma-derived (B) viral isolates from viral Donors 1, 2 or 3. CD4+ T cells and MDMs were isolated from the same blood donors. In (A), n = 11 cell donors for viral donor 1, n = 6 cell donors for viral donor 2, and n = 10 cell donors for viral donor 3; in (B), n = 9 cell donors for viral donor 1, n = 9 cell donors for viral donor 2, and n = 7 cell donors for viral donor 3. p value from Kruskal–Wallis test. Statistics compare the fold change at the final timepoint to day 1. **p < 0.01, ***p < 0.001.