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. 2021 Feb 16;11:3873. doi: 10.1038/s41598-021-83209-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Stellate cell morphological reconstruction. (A) Confocal microscopy imaging of four mouse SCs filled with Lucifer yellow (scale bar 10 μm) are shown along with the corresponding digital reconstruction with Neurolucida (visualization with Vaa3D simulator; right). The 3D morphological reconstructions of SCs include dendrites (blue), soma (black), AIS (green) and axon (red). (B) The SC model is divided into five electrotonic compartments and endowed with specific ionic mechanisms according to immunohistochemical data. The proximal and distal dendrites are distinguished at the cut-off diameter of 0.6 µm. Ionic channels include Na⁺, K⁺ and Ca²⁺ channels and a Ca²⁺ buffering system.