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. 2021 Feb 16;11:3873. doi: 10.1038/s41598-021-83209-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Burst currents at PF-SC and PF-PC cell synapses. (A) The traces show simulated SC EPSCs during trains of 20 stimuli delivered to PFs at different frequencies (4, 10, 20, 50, 100, 200 and 500 Hz; n = 4). Inset, NMDA, AMPA and NMDA + AMPA currents at 200 Hz. (B) The traces show simulated PC EPSCs during trains of 20 stimuli delivered to PFs at different frequencies (4, 10, 20, 50, 100, 200 and 500 Hz). (C) Gain curve for SC (blue circles; n = 4 for each frequency) and PC (red squares) responses with respect to input burst frequency. Gain is the ratio between the maximum response obtained at a certain frequency and the first EPSC. The gain curves show a sigmoidal shape with 50% amplitude around 50 Hz for the SC and around 10 Hz for the PC. Data in C corresponds to the cells in A and B.