Table 2.
Traits with moderate-high heritability () and total number of records >400 K with estimates for the variance captured by common SNPs ( with standard error s.e.) from unrelated pairs (; where is the genomic relationship), the heritability from close relatives (; either or ), the observed full-sib phenotypic correlation (), and its partitioning into common environment () and additive genetic effects (heritability, ).
Unrelated pairs () | Close relative pairs () | Full-sib pairs () | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Trait | N.records | N.pair | s.e. | N.pair | s.e. | N.pair | s.e. | s.e. | |||||
(×109) | ()a | ||||||||||||
height | 416,131 | 86.6 | 0.538 | 0.004 | 156,335 | 0.819 | 0.035 | 19,954 | 0.528 | 0.231 | 0.059 | 0.597 | 0.116 |
metRate | 409,465 | 83.8 | 0.306 | 0.003 | 151,279 | 0.623 | 0.027 | 19,368 | 0.329 | 0.034 | 0.080 | 0.596 | 0.160 |
pcc | 404,144 | 81.7 | 0.299 | 0.003 | 147,399 | 0.541 | 0.031 | 18,821 | 0.288 | 0.299 | 0.084 | −0.023 | 0.168 |
wbcc | 404,211 | 81.7 | 0.266 | 0.005 | 147,386 | 0.297 | 0.021 | 18,816 | 0.205 | 0.134 | 0.089 | 0.140 | 0.178 |
sit:stand | 414,868 | 86.0 | 0.254 | 0.003 | 155,416 | 0.430 | 0.028 | 19,841 | 0.244 | 0.156 | 0.086 | 0.177 | 0.173 |
rbcc | 404,317 | 81.7 | 0.249 | 0.003 | 147,527 | 0.490 | 0.026 | 18,841 | 0.246 | 0.172 | 0.087 | 0.148 | 0.174 |
BMI | 415,308 | 86.2 | 0.239 | 0.003 | 155,692 | 0.497 | 0.026 | 19,885 | 0.270 | −0.132 | 0.084 | 0.807 | 0.167 |
ecc | 402,539 | 81.0 | 0.231 | 0.004 | 146,276 | 0.255 | 0.022 | 18,682 | 0.175 | −0.096 | 0.092 | 0.543 | 0.184 |
bodyFat | 409,550 | 83.9 | 0.223 | 0.002 | 151,376 | 0.518 | 0.026 | 19,374 | 0.273 | 0.067 | 0.085 | 0.413 | 0.169 |
skinTan | 408,456 | 83.4 | 0.199 | 0.002 | 150,381 | 0.392 | 0.029 | 19,188 | 0.209 | 0.059 | 0.089 | 0.295 | 0.178 |
skinColour | 411,315 | 84.6 | 0.187 | 0.002 | 152,413 | 0.358 | 0.027 | 19,480 | 0.192 | −0.066 | 0.088 | 0.518 | 0.176 |
W:H | 416,167 | 86.6 | 0.165 | 0.002 | 156,364 | 0.370 | 0.023 | 19,958 | 0.197 | −0.096 | 0.088 | 0.588 | 0.175 |
handGrip | 416,124 | 86.6 | 0.144 | 0.002 | 156,279 | 0.350 | 0.027 | 19,957 | 0.182 | 0.114 | 0.089 | 0.137 | 0.178 |
EA | 413,496 | 85.5 | 0.133 | 0.002 | 153,925 | 0.421 | 0.043 | 19,736 | 0.295 | 0.222 | 0.083 | 0.144 | 0.165 |
The number of pairs (N.pair) contributing to each estimate is shown.
Traits include height, metabolic rate (metRate), platelet cell count (pcc), white blood cell count (wbcc), ratio of sitting to standing height (sit:stand), red blood cell count (rbcc), body mass index (BMI), eosinophil cell count (ecc), body fat percentage (bodyFat), skin tanning (skinTan), skin colour (skinColour), waist-to-hip ratio (W:H), hand grip strength (handGrip) and educational attainment (EA). Further trait details are given in Supplementary Table 1.
a presented for most traits. For traits with significant assortative mating (height and EA); the value is the equilibrium heritability ().