Table 1.

The developmental history of Alcon’s acrylic lenses [1, 2] (R. Packard, personal communication with GUA, August 2020; W. Graham, personal communication with GUA, August 2020)

Year	Development event
1990	First implantations of the MA60AL multipiece Acrysof IOL in Windsor, UK, and New Orleans, LA, USA, on December 14 (surgeons: Packard and Brint, respectively)
1991–1992	MA60AL: European Core Study and parallel FDA clinical study
1994	Multipiece MA60AL model approvals: CE mark (notified body TUV) and FDA pre-market approval
1995	Development of Acrysof single-piece design Problems with “Acrysert” pack and glistenings lead to product withdrawal in the USA
1997	Single-piece clinical studies start
1999	Single-piece clinical studies completed
2000	Single-piece Acrysof approval and market release
2001	New variations of one-piece for smaller incision injection
2003	“Yellow” Acrysof Natural available. Multifocal Acrysof ReSTOR launched outside the USA. Trials on Acrysof toric and Wavefront IOLs begin
2005	Launch of Acrysof toric and IQ lenses
2007	Acrysof Aspheric ReSTOR+ 3.0 launched in Europe
2010	Acrysof Aspheric ReSTOR Toric launched in Europe
2012	Acrysof Aspheric ReSTOR+ 2.5 launched in Europe
2013	Thomes & Callaghan report on improved manufacturing process—improvements to minimize glistenings
2015	Acrysof PanOptix launched outside the USA
2017	Clareon introduced in Europe