Table 1.
Characteristics of patients labeled as having moderate-to-severe thyroid eye disease
| Patient characteristics | All patients (N = 714) | Moderate TED (n = 612) | Severe TED (n = 102) | P valuea |
|---|---|---|---|---|
| Number (%) of patients of an ophthalmologist | 432 (61) | 370 (61) | 62 (61) | > 0.999 |
| Number (%) of women | 466 (65) | 398 (65) | 68 (67) | 0.835 |
| Age, mean (SD), years | 49.4 (13.6) | 49.5 (13.7) | 49.4 (12.7) | 0.949 |
| Number (%) of euthyroid patients | 555 (78) | 477 (78) | 78 (76) | 0.840 |
| Number (%) of patients with Graves’ disease | 487 (68) | 405 (66) | 82 (80) | 0.006 |
| TED duration, mean (SD), years | 4.2 (5.1) | 4.2 (5.1) | 4.2 (5.2) | 0.979 |
| Number (%) of patients with higher overall QOL impact (score ≥ 4) | 473 (66) | 382 (62) | 91 (89) | < 0.001 |
| Overall QOL impact score, mean (SD)b | 4.1 (1.5) | 4.0 (1.5) | 5.2 (1.3) | < 0.001 |
| Ability to attend work/school, mean (SD) | 3.5 (1.7) | 3.3 (1.6) | 4.8 (1.6) | < 0.001 |
| Ability to function in social situations, mean (SD) | 4.0 (1.6) | 3.8 (1.6) | 5.1 (1.4) | < 0.001 |
| Ability to participate in daily activities, mean (SD) | 3.8 (1.6) | 3.6 (1.5) | 5.0 (1.4) | < 0.001 |
| Ability to drive, mean (SD) | 3.6 (1.7) | 3.3 (1.7) | 5.0 (1.5) | < 0.001 |
| Psychological well-being, mean (SD) | 4.1 (1.5) | 3.9 (1.5) | 5.2 (1.3) | < 0.001 |
| Number (%) of patients with mental health issuesc | 260 (36) | 230 (38) | 30 (29) | 0.140 |
| Number (%) of patients with anxiety | 188 (26) | 174 (28) | 14 (14) | 0.003 |
| Number (%) of patients with depression | 131 (18) | 109 (18) | 22 (22) | 0.442 |
QOL Quality of life, SD standard deviaiton, TED thyroid eye disease
aComparisons of patients with moderate and severe TED were performed using a 2-tailed Student’s t test or chi-square test, as appropriate
bOverall and subscale QOL were scored by physicians using a Likert scale, ranging from 1 (not at all impaired) to 7 (extremely impaired)
cAnxiety and/or depression