TABLE 2.
Association and meta-analysis results for the independent SNPs identified in Hispanics/Latinos followed up for replication in African Americans
| rsID | Chr.: position (bp)a | A1/A2 | Closest gene | GALA II (n = 3310) | SAGE (n = 1043) | Meta-analysis (n = 4353) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Freq.b | OR (95% CI)b | P-valueb | Freq.b | OR (95% CI)b | P-valueb | OR (95% CI)b | P-valueb | Model | ||||
| rs4952375 | 2:42 016 863 | A/T | snoZ247/UNC01913 | 0.23 | 1.37(1.20–1.55) | 1.24 × 10−6 | 0.10 | 1.53 (1.12–2.08) | 7.43 × 10−3 | 1.39(1.23–1.56) | 3.79 × 10−8 | FE |
| rs17759529 | 2:162 851 013 | G/C | DPP4 | 0.16 | 0.67 (0.58–0.77) | 6.35 × 10−8 | 0.14 | 0.91 (0.69–1.18) | .467 | 0.76 (0.57–1.02) | 3.80 × 10−7 | RE2 |
| rs187089444 | 3:174 519 230 | A/C | NAALADL2 | 0.03 | 2.19 (1.60–2.99) | 8.70 × 10−7 | NA | NA | NA | NA | NA | NA |
| rs181042383 | 4:14 887 486 | A/G | UNC00504/CPEB2-DT | 0.04 | 1.95 (1.49–2.56) | 1.35 × 10−6 | NA | NA | NA | NA | NA | NA |
| rs78968521 | 4:152 214 673 | G/A | PRSS48 | 0.02 | 2.38(1.68–3.38) | 1.16 × 10−6 | 0.01 | 0.69 (0.31–1.54) | .360 | 1.35 (0.40–4.55) | 1.45 × 10−5 | RE2 |
| rs112599943 | 6:133 499 724 | C/T | EYA4 | 0.04 | 1.92 (1.47–2.50) | 1.55 × 10−6 | 0.08 | 1.40(1.00–1.95) | .047 | 1.70(1.38–2.09) | 6.00 × 10−7 | FE |
| rs76605301 | 10:12 227 306 | T/C | NUDT5 | 0.03 | 2.14 (1.56–2.94) | 2.87 × 10−6 | NA | NA | NA | NA | NA | NA |
| rs591709 | 11:93 520 315 | T/C | MED17 | 0.15 | 0.70 (0.60–0.81) | 2.39 × 10−6 | 0.20 | 1.28 (1.02–1.60) | .037 | 0.94 (0.52–1.70) | 9.65 × 10−6 | RE2 |
| rs11613333 | 12:116 880 378 | C/T | MIR4472–2 | 0.42 | 1.34(1.20–1.50) | 2.90 × 10−7 | 0.08 | 1.22 (0.87–1.71) | .243 | 1.33 (1.20–1.48) | 1.64 × 10−7 | FE |
| rs12946510 | 17:37 912 377 | T/C | GRB7/IKZF3 | 0.32 | 0.68 (0.60–0.76) | 6.82 × 10−11 | 0.21 | 0.85 (0.67–1.07) | .164 | 0.71 (0.64–0.79) | 1.12 × 10−10 | FE |
| rs113516984 | 17:45 964 442 | C/T | RP11–6N17.4/SP2 | 0.11 | 0.66 (0.56–0.79) | 4.64 × 10−6 | 0.07 | 0.67 (0.43–1.02) | .064 | 0.66(0.56–0.78) | 7.82 × 10−7 | FE |
| rs6132057 | 20:18 390 980 | G/A | DZANK1 | 0.15 | 0.69 (0.59–0.81) | 3.33 × 10−6 | 0.07 | 1.33 (0.93–1.91) | .117 | 0.94 (0.49–1.79) | 2.58 × 10−5 | RE2 |
Abbreviations: A1, effect allele; A2, non-effect allele; Chr., chromosome; CI, confidence interval; FE, fixed-effects model; Freq., effect allele frequency; NA, not available/applicable; OR, odds ratio; RE2, Han and Eskin’s random-effects models; rsID, reference SNP identifier.
a
Coordinates are referred to the GRCh37 reference genome.
b
Referred to the effect alleles (additive model).