Table 1.
Summary of the studies in human tumors using scRNAseq.
| Cancer type | Tumor cell types | scRNAseq method | Cell number | References | |
|---|---|---|---|---|---|
| Follicular B-cell lymphomas | Cancer tissue cells | 10×Genomics | 34,188 | (16) | |
| Breast cancer (TNBC) | CD3+ TILs | 10×Genomics and Fluidigm C1 | 6,311 | (17) | |
| Breast cancer (TNBC) | PDX | 10×Genomics | 3,500 | (18) | |
| Breast cancer (TNBC) | M6-Ctrl,M6-Hh cells | 10×Genomics | 14,950 | (19) | |
| Breast cancer | Cancer epithelial cells | 10×Genomics and Fluidigm C1 | 24,646 | (20) | |
| Gliomas | Inter (CD11b+) and Intra tumor TAMs (in silico) | 10×Genomics and Fluidigm C1 | 5,455 | (21) | |
| Gastric Premalignant Lesions and Early Gastric Cancer | Cancer epithelial cells | 10×Genomics | 56,440 | (22) | |
| Melanoma | PDX | 10×Genomics | 8,700 | (23) | |
| Melanoma Merkel cell carcinoma (MCC) Leukemia Human kidney tumors Hepatocellular carcinoma (HCC) Hepatocellular carcinoma Hepatocellular carcinoma Pancreatic ductal adenocarcinoma Human glioblastomas |
451Lu-Par, 451Lu-BR, A375-BR,451Lu-BR3 cells Cancer tissue cells CMVpp65- or PRAME-specific T cells normal and cancerous kidney cells circulating tumor cells (CTCs) HuH1 and HuH7 cell lines T cells pancreatic cells EGFR wild-type and EGFRvIII mutant cells |
10×Genomics 10×Genomics 3’ Chromium 10×Genomics 10×Genomics 10×Genomics 10x Genomics 10×Genomics 10×Genomics 10×Genomics |
6,500 11,021 5,000 72,501 7,104 3,847 5,063 57,530 16,128 |
(24) (25) (26) (27) (28) (29) (30) (31) (32) |
|
| Non-small-cell lung cancer (NSCLC) | stromal cells | 10×Genomics | 84,381 | (33) | |
| T-cell acute lymphoblastic leukemia (T-ALL) | T-ALL cells | 10×Genomics | 2,074 | (34) | |
| Alveolar Rhabdomyosarcoma (ARMS) Head and neck squamous cell carcinoma (HNSCC) |
circulating tumor cells Cancer tissue cells |
10×Genomics 10×Genomics |
416 5,902 |
(35) (36) |
|