Table 2.
Correlation analysis between CR3, CR4, C5aR1, CD55 and relate immune genes markers dependently in STAD and COAD via TIMER.
| Description | Gene markers | C3(STAD) | CR4 (STAD) | C5aR1 (STAD) | CD55 (COAD) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| None | Purity | None | Purity | None | Purity | None | Purity | ||||||||||
| Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | ||
| T cell (general) | CD3D | 0.444 | *** | 0.402 | *** | 0.518 | *** | 0.477 | *** | 0.432 | *** | 0.382 | *** | 0.245 | *** | 0.149 | 2.56e-03 |
| CD3E | 0.491 | *** | 0.457 | *** | 0.505 | *** | 0.464 | *** | 0.399 | *** | 0.356 | *** | 0.273 | *** | 0.179 | 2.84e-04 | |
| CD2 | 0.482 | *** | 0.451 | *** | 0.577 | *** | 0.549 | *** | 0.478 | *** | 0.45 | *** | 0.285 | *** | 0.2 | 4.89e-05 | |
| Monocyte | CD86 | 0.442 | *** | 0.396 | *** | 0.809 | *** | 0.796 | *** | 0.809 | *** | 0.799 | *** | 0.359 | *** | 0.273 | *** |
| CD115 (CSF1R) | 0.551 | *** | 0.519 | *** | 0.749 | *** | 0.743 | *** | 0.799 | *** | 0.793 | *** | 0.229 | *** | 0.123 | 1.34e-02 | |
| TAM | CCL2 | 0.461 | *** | 0.429 | *** | 0.457 | *** | 0.394 | *** | 0.554 | *** | 0.517 | *** | 0.203 | 1.2e-05 | 0.107 | 3.05e-02 |
| CD68 | 0.259 | *** | 0.222 | *** | 0.632 | *** | 0.608 | *** | 0.648 | *** | 0.632 | *** | 0,363 | *** | 0.3 | *** | |
| IL10 | 0.411 | *** | 0.383 | *** | 0.623 | *** | 0.581 | *** | 0.703 | *** | 0.681 | *** | 0.248 | *** | 0.182 | 2.24e-04 | |
| M1 Macrophage | INOS (NOS2) | −0.024 | 0.62 | −0.047 | 0.366 | 0.167 | 6.67e-04 | 0.151 | 3.22e-03 | 0.141 | 0.225 | 0.123 | 0.199 | -0.041 | 7.23e-01 | -0.068 | 5.65e-01 |
| IRF5 | 0.3 | *** | 0.266 | *** | 0.343 | *** | 0.324 | *** | 0.347 | *** | 0.344 | *** | 0.138 | 2.24e-01 | 0.155 | 1.91e-01 | |
| COX2(PTGS2) | 0.045 | 0.359 | 0.02 | 0.694 | 0.125 | 1.07e-02 | 0.096 | 6.21e-02 | 0.139 | *** | 0.304 | *** | 0.101 | 3.74e-01 | 0.132 | 2.64e-01 | |
| M2 Macrophage | CD163 | 0.459 | *** | 0.42 | *** | 0.754 | *** | 0.743 | *** | 0.863 | *** | 0.856 | *** | 0.128 | 2.59e-01 | 0.157 | 1.85e-01 |
| VSIG4 | 0.442 | *** | 0.421 | *** | 0.646 | *** | 0.629 | *** | 0.783 | *** | 0.776 | *** | 0.098 | 3.88e-01 | 0.128 | 2.81e-01 | |
| MS4A4A | 0.455 | *** | 0.419 | *** | 0.74 | *** | 0.724 | *** | 0.815 | *** | 0.808 | *** | 0.109 | 3.37e-01 | 0.167 | 1.58e-01 | |
| Dendritic cell | HLA-DPB1 | 0.482 | *** | 0.441 | *** | 0.586 | *** | 0.542 | *** | 0.572 | *** | 0.543 | *** | 0.143 | 2.08e-02 | 0.207 | 7.85e-02 |
| HLA-DQB1 | 0.312 | *** | 0.258 | *** | 0.52 | *** | 0.474 | *** | 0.44 | *** | 0.401 | *** | 0.154 | 1.75e-01 | 1.279 | 1.29e-01 | |
| HLA-DRA | 0.406 | *** | 0.367 | *** | 0.626 | *** | 0.504 | *** | 0.581 | *** | 0.563 | *** | 0.085 | 4.53e-01 | 0.133 | 2.61e-01 | |
| HLA-DPA1 | 0.45 | *** | 0.413 | *** | 0.602 | *** | 0.571 | *** | 0.58 | *** | 0.56 | *** | 0.161 | 1.56e-01 | 0.218 | 6.93e-02 | |
| BDCA-1(CD1C) | 0.462 | *** | 0.421 | *** | 0.44 | *** | 0.291 | *** | 0.352 | *** | 0.307 | *** | 0.139 | 2.23e-01 | 0.205 | 8.14e-02 | |
| BDCA-4(NRP1) | 0.474 | *** | 0.432 | *** | 0.535 | *** | 0.505 | *** | 0.661 | *** | 0.64 | *** | 0.097 | 3.95e-01 | 0.077 | 5.18e-01 | |
| CD11c(ITGAX) | 0.447 | *** | 0.409 | *** | / | / | / | / | 0.803 | *** | 0.788 | *** | 0.065 | 5.67e-01 | 0.05 | 6.74e-01 | |
| Treg | FOXP3 | 0.488 | *** | 0.453 | 0.488 | 0.591 | *** | 0.567 | *** | 0.49 | *** | 0.469 | *** | 0.043 | 7.07e-01 | 0.023 | 8,45e-01 |
| CCR8 | 0.458 | *** | 0.436 | 0.458 | 0.678 | *** | 0.683 | *** | 0.615 | *** | 0.614 | *** | 0.148 | 1.94e-01 | 0.171 | 1.48e-01 | |
| STAT5B | 0.424 | *** | 0.407 | 0.424 | 0.356 | *** | 0.36 | *** | 0.452 | *** | 0.464 | *** | 0.246 | 2.88e-02 | 0.243 | 3.82e-01 | |
| TGFβ (TGFB1) | 0.498 | *** | 0.467 | 0.498 | 0.419 | *** | 0.384 | *** | 0.5 | 0.011 | -0.233 | *** | 0.061 | 5.91e-01 | 0.097 | 4.15e-01 | |
| T cell exhaustion | PD-1 (PDCD1) | 0.377 | *** | 0.346 | 0.377 | 0.485 | *** | 0.458 | *** | 0.381 | *** | 0.359 | *** | 0.067 | 5.59e-01 | 0.152 | 1.99e-01 |
| CTLA4 | 0.332 | *** | 0.294 | 0.332 | 0.502 | *** | 0.469 | *** | 0.409 | *** | 0.382 | *** | 0.105 | 3.59e-01 | 0.142 | 2.32e-01 | |
| LAG3 | 0.336 | *** | 0.309 | 0.336 | 0.465 | *** | 0.442 | *** | 0.412 | *** | 0.384 | *** | -0.063 | 5.83e-01 | -0.087 | 4.62e-01 | |
| TIM-3(HAVCR2) | 0.44 | *** | 0.404 | 0.44 | 0.814 | *** | 0.806 | *** | 0.806 | *** | 0.8 | *** | 0.157 | 1.66e-01 | 0.197 | 9.55e-02 | |
| GZMB | 0.209 | *** | 0.161 | 0.209 | 0.41 | *** | 0.367 | *** | 0.375 | *** | 0.339 | *** | -0.045 | 6.94e-01 | -0.025 | 8.37e-01 | |
STAD, stomach adenocarcinoma; Tumor, correlation analysis in tumor tissue of TCGA; Normal, correlation analysis in normal tissue of TCGA. *P < 0.01; **P < 0.001; ***P < 0.0001.