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Increased spleen size, autoantibodies, and renal dysfunction in mCD40-LMP1 vs. mCD40 WT over time after EBNA-1 immunization. Mean ± SEM spleen size (A), serum ANA (B), serum anti-dsDNA (C), serum BUN (D), and serum creatinine (E) levels at 10, 28, and 56 days post-EBNA1 immunization (vs. adjuvant/naïve control) in mCD40-LMP1 Tg vs. mCD40 WT mice. *p ≤ 0.05, **p ≤ 0.01, ***p < 0.001, ****p < 0.0001 one way ANOVA with Dunnett’s multiple comparison test.
