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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Anesth Analg. 2021 Mar 1;132(3):878–889. doi: 10.1213/ANE.0000000000005268

Figure 6. Clonidine mitigates sevoflurane-induced cognitive impairment in young mice.

Figure 6.

Escape latency (A) and platform crossing number (B) of young mice on the MWM test compared to vehicle after clonidine treatment. Escape latency (C) and platform crossing number (D) on the MWM test after pretreatment with clonidine followed by sevoflurane treatment. E. Ratio of exploring novel object time to the total object time on the NOR test compared to vehicle after clonidine treatment. F. Ratio of exploring novel object time to the total object time on the NOR test compared to control in young mice pretreated with clonidine followed by sevoflurane. NOR, New Object Recognition Test; MWM; Morris Water Maze; P, postnatal. A two-way ANOVA and Mann-Whitney U test were used to analyze the data. N = 12 in each group.