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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Pharmacol Ther. 2020 Oct 9;219:107704. doi: 10.1016/j.pharmthera.2020.107704

Figure 6: MLK3 regulates PPIase activity in tumor and T cells.

Figure 6:

MLK3 phosphorylates Pin1 and Ppia and induce PPIase activities. In breast cancer, MLK3 phosphorylates Pin1 and increases PPIase activity, and promotes Cdc2 mediated cancer cell proliferation. In T cells, MLK3 phosphorylates Ppia and increases PPIase activity and attenuates T cell effector function. Where, Cdc2, cell division cycle 2; MLK3, mixed lineage kinase 3; Pin1, peptidylprolyl cis/trans isomerase, NIMA-Interacting 1; Ppia, peptidylprolyl isomerase A.