Table 1:
Patient Variables by Sex
| Variable | Male (n=63) | Female (n=71) | p-value |
|---|---|---|---|
| Age (years)* | 37.4±9.1 | 36.7±8.9 | 0.64 |
| T1D Duration (years)* | 22.8±8.4 | 23.8±7.9 | 0.49 |
| Race (NHW)† | 65 (98.5%) | 75 (94.9%) | 0.24 |
| Current Smokers† | 9 (13.9%) | 8 (10.1%) | 0.49 |
| Ever Smokers† | 12 (18.5%) | 21 (26.6%) | 0.25 |
| Hypertension† | 38 (57.6%) | 34 (43.0%) | 0.081 |
| Average Systolic BP (mm Hg)* | 123.9±16.1 | 113.9±13.7 | <0.0001 |
| Average Diastolic BP (mm Hg)* | 81.2±8.8 | 74.8±8.3 | <0.0001 |
| CAC (present)† | 28 (42.2%) | 26 (32.9%) | 0.24 |
| On lipid-lowering medications† | 15 (22.7%) | 11 (13.9%) | 0.17 |
| On HMG-CoA reductase inhibitors† | 14 (21.2%) | 10 (12.7%) | 0.17 |
| On anti-hypertensive medications† | 30 (45.5%) | 30 (37.9%) | 0.36 |
| BMI (kg/m2)* | 27.0±4.1 | 25.7±4.6 | 0.056 |
| Average Waist Circumference (cm)* | 91.4±10.4 | 81.3±12.1 | <0.0001 |
| HbA1C (%)‡ | 7.5 (6.9, 8.2) | 7.5 (6.9, 8.4) | 0.64 |
| Insulin Dose (units/day/kg body wt)* | 0.69±0.24 | 0.62±0.32 | 0.14 |
| Adiponectin (μg/mL)* | 12.8±7.5 | 17.3±8.5 | 0.0010 |
| eIS (mg/kg/min)‡ | 4.7 (3.2, 6.4) | 7.3 (5.4, 9.8) | <0.0001 |
| Plasma Lipid Panel: | |||
| Total cholesterol (mg/dL)* | 169.4±37.4 | 171.4±30.4 | 0.72 |
| LDL cholesterol (mg/dL)* | 100.4±31.3 | 93.3±25.1 | 0.13 |
| HDL cholesterol (mg/dL)* | 48.3±12.5 | 60.6±16.4 | <0.0001 |
| Triglycerides (mg/dL)‡ | 85 (59, 112) | 70 (55, 99) | 0.19 |
| APOB (mg/dL)* | 94.0±27.3 | 83.9±19.1 | 0.010 |
| HDL APOC3 (AU)ठ| 0.89 (0.60, 1.17) | 0.95 (0.68, 1.33) | 0.46 |
| Serum APOC3 (AU)ठ| 0.88 (63, 1.19) | 0.99 (0.75, 1.17) | 0.54 |
| Non-HDL cholesterol (mg/dL)* | 119.4±34.9 | 110.8±27.9 | 0.10 |
| Serum RBP4 (AU)*§ | 1.17±0.48 | 0.88±0.41 | 0.0001 |
| HDL RBP4 (AU)*§ | 1.06±0.58 | 0.99±0.49 | 0.40 |
Numbers presented as mean±SD(*), median (25th, 75th percentile)‡ or number (%)†
§
AU, arbitrary unit (measured as fold changes with mean set to 1)
Significant differences are indicated by bold font