Table 4 -.

Increased odds of perioperative transfusion associated with the given values of hemoglobin and platelets

	Platelet count (per μL)
	50×109	100×109	150×109	300×109	400×109
Females
Hemoglobin = 8 g/dL	18.71 (13.95, 25.09)	16.08 (12.85, 20.11)	13.82 (11.69, 16.32)	10.97 (9.61, 12.51)	11.95 (10.46, 13.65)
Hemoglobin = 10 g/dL	6.50 (5.60, 7.54)	5.39 (4.80, 6.04)	4.47 (4.09, 4.88)	3.39 (3.13, 3.67)	3.83 (3.53, 4.14)
Hemoglobin = 13 g/dL	1.63 (1.52, 1.75)	1.28 (1.23, 1.32)	Referent	0.71 (0.67, 0.75)	0.85 (0.79, 0.91)
Hemoglobin = 15 g/dL	1.20 (1.02, 1.40)	0.89 (0.79, 1.01)	0.66 (0.60, 0.73)	0.44 (0.40, 0.49)	0.57 (0.50, 0.65)
Males
Hemoglobin = 8 g/dL	16.70 (12.70, 21.97)	14.35 (11.67, 17.65)	12.34 (10.55, 14.42)	9.79 (8.45, 11.34)	10.67 (9.18, 12.39)
Hemoglobin = 10 g/dL	6.17 (5.36, 7.11)	5.12 (4.60, 5.71)	4.25 (3.90, 4.62)	3.22 (2.96, 3.51)	3.64 (3.34, 3.96)
Hemoglobin = 13 g/dL	1.63 (1.52, 1.75)	1.28 (1.23, 1.32)	Referent	0.71 (0.67, 0.75)	0.85 (0.79, 0.91)
Hemoglobin = 15 g/dL	1.09 (0.95, 1.24)	0.81 (0.74, 0.89)	0.60 (0.57, 0.64)	0.40 (0.38, 0.43)	0.52 (0.45, 0.59)

Estimates are odds ratios and reflect the increased odds of event associated with the given hemoglobin/platelet combination. Estimates are from multivariable logistic regression including the linear and spline terms for hemoglobin and platelet count as well as their interactions, interactions between sex and hemoglobin terms, and ASA PS, procedure type, type of anesthesia, and comorbidities (cancer, lymphoma, leukemia, liver disease, renal disease, MI, CHF, stroke, prior anti-platelet medication, and prior anticoagulation medication). Reference values for hemoglobin and platelet count are 13g/dL and 150×10⁹/L respectively