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. Author manuscript; available in PMC: 2022 Feb 15.
Published in final edited form as: Chemistry. 2020 Dec 15;27(10):3229–3237. doi: 10.1002/chem.202003523

Figure 7.

Figure 7.

(a) Synthesis route of TB@Hf-BDC-PEG and (b) mechanisms of therapeutic activity include radiosensitization through hafnium-mediated ROS enhancement following irradiation whereas the second mechanism involves the delivery of DNA damage repair (DDR) inhibitors. (c) Representative images of ɣH2AX foci in 4T1 cells treated with no drug, Hf-BDC-PEG, or TB@Hf-BDC-PEG and +/− RT. Nuclei were stained for DAPI (blue) and ɣH2AX (red). Scale bars represent 100 μm. Adapted with permission.[34] Copyright 2020, Springer.