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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Curr Genet. 2020 Oct 20;67(1):85–92. doi: 10.1007/s00294-020-01116-5

Figure 1: Role of nuclear Pif1 in different biological DNA transactions.

Figure 1:

Pif1 functions in (A) flap lengthening during Okazaki fragment processing; (B) modulating fork convergence during replication termination; (C) aiding G4 structure resolution; (D) promoting break-induced replication; (E) unwinding R-loops; and (F) regulating telomere length. Acetylation of Pif1 mediated by the lysine acetyltransferase NuA4 (Esa1) and lysine deacetylase (Rpd3) may play a regulatory role in how Pif1’s functions are altered in all of these outlined pathways. Triple arrows indicate directionality of Pif1 activity.