Table 3.

Associations of polygenic and genetic risk scores of coronary artery disease with primary incident CAD in the UK Biobank

Genetic predisposition*		All HR (95% CI)	Men HR (95% CI)	Women HR (95% CI)	Interaction P-value
CAD-GRS	Per SD increase	1.34 (1.31, 1.36)	1.38 (1.34, 1.41)	1.25 (1.21, 1.30)	5×10−5
	Intermediate	1.44 (1.35, 1.53)	1.50 (1.40, 1.62)	1.30 (1.17, 1.45)	2×10−3
	High	2.20 (2.06, 2.35)	2.39 (2.21, 2.59)	1.82 (1.62, 2.05)
GRSCAD-BP	Per SD increase	1.14 (1.12, 1.16)	1.17 (1.14, 1.20)	1.08 (1.04, 1.12)	4×10−4
	Intermediate	1.17 (1.11, 1.23)	1.20 (1.13, 1.28)	1.09 (0.99, 1.20)	5×10−4
	High	1.42 (1.34, 1.51)	1.54 (1.43, 1.66)	1.19 (1.06, 1.33)
GRSCAD-lipids	Per SD increase	1.18 (1.16, 1.21)	1.19 (1.17, 1.22)	1.16 (1.12, 1.20)	0.17
	Intermediate	1.21 (1.14, 1.28)	1.25 (1.17, 1.33)	1.13 (1.02, 1.24)	0.23
	High	1.57 (1.47, 1.67)	1.60 (1.48, 1.73)	1.49 (1.34, 1.67)
GRSCAD-BMI	Per SD increase	1.08 (1.06, 1.10)	1.07 (1.05, 1.10)	1.08 (1.05, 1.12)	0.47
	Intermediate	1.13 (1.07, 1.19)	1.15 (1.08, 1.22)	1.10 (0.99, 1.21)	0.67
	High	1.25 (1.17, 1.33)	1.25 (1.16, 1.35)	1.24 (1.10, 1.38)
CAD-LDpred	Per SD increase	1.36 (1.33, 1.39)	1.39 (1.36, 1.43)	1.29 (1.24, 1.33)	3×10−3
	Intermediate	1.51 (1.42, 1.60)	1.59 (1.47, 1.71)	1.33 (1.20, 1.49)	7×10−3
	High	2.35 (2.20, 2.51)	2.55 (2.35, 2.77)	1.95 (1.73, 2.19)

^*When scores were categorized, participants with low genetic risk (quintile 1) for each score were used as the reference group