Table 2:
Characteristics of spinal fusion subjects with and without ischemic optic neuropathy in the Clinformatics® Data Mart database using pre-admission information
| Spinal fusion with ION (cases) | Spinal fusion without ION (controls) | Comparison | ||||
|---|---|---|---|---|---|---|
| Full set | Matched set | full set* | matched set** | |||
| n=65 | n=106,871 | n=211 | P value | Odds ratio | P value | |
| Demographics | ||||||
| Age, mean ± SD | 66.1 ± 9.5 | 58.5 ± 13.6 | 61.3 ± 13.3 | <.001 | ||
| Age category, n(%) | <.001 | < 0.15 | ||||
| 18-<57 | <10 | 44018 (41.2) | 55 (26.1) | |||
| 57–65 | 23 (35.4) | 26503 (24.8) | 43 (20.4) | |||
| 66–74 | 19 (29.2) | 23868 (22.3) | 71 (33.7) | |||
| >75 | 14 (21.5) | 12482 (11.7) | 42 (19.9) | |||
| Female, n(%) | 27 (41.5) | 60542 (56.7) | 137 (64.9) | 0.01 | 0.43 (0.23, 0.8) | 0.01 |
| Chronic conditions (PA information), n(%) | ||||||
| Atherosclerosis | <10 | 9447 (8.84) | 23 (10.90) | ≥ 0.15 | ||
| Anemia | 19 (29.23) | 29655 (27.75) | 63 (29.86) | 0.79 | 1.23 (0.61, 2.46) | 0.56 |
| Carotid artery stenosis | <10 | 6063 (5.67) | 15 (7.11) | < 0.15 | ||
| Cerebrovascular disease | <10 | 1062 (0.99) | <10 | ≥ 0.15 | ||
| Chronic kidney disease | <10 | 9112 (8.53) | 24 (11.37) | ≥ 0.15 | ||
| Diabetes mellitus | <.001 | 0.003 | ||||
| Complications | 11 (16.9) | 10438 (9.77) | 22 (10.43) | 3.21 (1.24, 8.33) | ||
| No complications | 20 (30.77) | 18204 (17.03) | 27 (12.80) | 2.99 (1.42, 6.31) | ||
| No diabetes | 34 (52.31) | 78229 (73.2) | 162 (76.78) | Ref | ||
| Heart failure | <10 | 7184 (6.72) | 11 (5.21) | < 0.15 | ||
| Hypercoagulability | <10 | 823 (0.77) | <10 | 0.48 | ≥ 0.15 | |
| Hyperlipidemia | 53 (81.54) | 68514 (64.11) | 142 (67.30) | 0.00 3 | 2.07 (1.01, 4.23) | 0.05 |
| Hypertension | 57 (87.69) | 72973 (68.28) | 151 (71.56) | <.001 | 2.61 (1.11, 6.13) | 0.03 |
| Ischemic heart disease | <10 | 4917 (4.6) | <10 | ≥ 0.15 | ||
| Obesity | 19 (29.23) | 30799 (28.82) | 65 (30.81) | 0.94 | 1.16 (0.61, 2.19) | 0.65 |
| Obstructive sleep apnea | 14 (21.54) | 15151 (14.18) | 28 (13.27) | 0.09 | 2.1 (0.93, 4.77) | 0.08 |
| Smoking | 19 (29.23) | 40575 (37.97) | 75 (35.55) | 0.15 | 0.99 (0.53, 1.85) | 0.97 |
| Thrombocytopenia | <10 | 3380 (3.16) | <10 | ≥0.15 | ||
| Chronic ophthalmic conditions (PA information), n(%) | ||||||
| AMD | <10 | 3582 (3.35) | 12 (5.69) | 0.21 | 1.46 (0.41, 5.16) | ≥ 0.15 |
| Cataract category | 0.16 | ≥ 0.15 | ||||
| Surgery | <10 | 6547 (6.13) | 19 (9.00) | 1.47 (0.50, 4.30) | ||
| No surgery | 15 (23.08) | 17469 (1635) | 52 (24.64) | 1.12 (0.55, 2.30) | ||
| No Cataract | 44 (67.69) | 82855 (77.53) | 140 (66.35) | Ref | ||
| Glaucoma | 11 (16.92) | 8661 (8.10) | 22 (10.43) | 0.00 9 | 1.4 (0.61, 3.21) | 0.42 |
| HTN retinopathy | <10 | 1030 (0.96) | <10 | ≥ 0.15 | ||
*
t-test for continuous variables or chi-square for categorical variables, p value not reported for if <10 subjects in either group
**
conditional logistic regression, unadjusted odds ratios, p value reported relative to threshold of 0.15 if < 10 subjects in either group
ION ischemic optic neuropathy, AMD age related macular degeneration, HTN hypertensive