Table 1.

Baseline values of rate constants

Name	Description	Value (min−1)
k1	endosomal escape	10 −2
k2	complex formation between pDNA and nuclear import protein	2 × 10 −3
k3	pDNA degradation	5 × 10 −3
k4	association of pDNA complex with NPC	103
k5	entry of pDNA complex into the nucleus	3 × 10 −3
k6	dissociation of pDNA from nuclear import protein	103
k7	protein production	10 −2
k8	protein degradation	7.7 × 10 −4

Note: The values of k₁ through k₇ were obtained from Ref.[17], and the value of k₈ was calculated based on the intracellular half-life of enhanced green fluorescence protein (15 h) [24].