Table 3.

Summary of host factors associated with MDM antigen presentation and Mtb growth in-vitro, with and without rapamycin ^a

^aSample sizes, measurement units and detailed statistics shown in Tables S3A-B; Green background = beneficial response vs Mtb (e.g. ↑ IL-2 or ↓ CFUs); Red background = Compromised response to Mtb (e.g. ↓ IL-2 or ↑ CFUs); No background = No association; Vertial arrows (↑, ↓) indicate the direction of associations for categorical variables with referent category indicated next to each variable; Slanted arrows (↗, ↘) indicated the direction of correlations for continuous variables; Arrows alone, significant associations (p ≤ 0.05); Arrows with “(bor)”, borderline significant (0.051 ≥ p ≤ 0.09);

Definitions and abbreviations: All = All study participants (contacts, healthy and TB); BMI = Body-mass index; C = TB contacts; CFU = Mtb colony-forming units; DM = Diabetes; Glycemic index = HbA_1c x years with DM; H= healthy controls; MDM = Monocyte-derived macrophage; TB = Tuberculosis patients; WHR = Waist:Hip ratio; Vacular diseases are self-reported;