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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Neuropharmacology. 2020 Dec 11;185:108437. doi: 10.1016/j.neuropharm.2020.108437

Figure 3:

Figure 3:

Between-subjects effects of chronic co-administration of MNTX and 10 mg/kg morphine in a warm-water tail-withdrawal assay. Panels A-B show antinociceptive response (%MPE) on Day 1 and Day 7, respectively, to cumulative doses of morphine in mice pretreated with either saline, 0.1-10 mg/kg MNTX, or 1 mg/kg NTX. SAL + VEH refers to mice assigned to receive chronic co-administration of saline (morphine vehicle) and saline (vehicle for MNTX and NTX). MOR refers to mice receiving chronic administration of 10 mg/kg morphine (s.c.) once daily along with the respective co-treatment condition on Days 2-6. Values represent mean %MPE of 6-12 mice per condition. Error bars are omitted for clarity but are included in the within-subjects presentation of this data in Figure 4. Significant differences (p<0.05) in %MPE compared to the respective saline + antagonist test condition are denoted by filled symbols.