Figure 6: OX40 agonist improves survival in sepsis.
C57BL/6J mice were injected with 200μg OX40 agonistic antibody 6 hours after CLP and again at 48 hours. Septic control animals received isotype control. Survival was recorded for 7 days. Mice receiving OX40 agonist had a markedly improved survival. Data was analyzed by Gehan-Breslow-Wilcoxon test.