Table 2.

Association^* between Fibrosis-4 Liver Fibrosis Score and Perihematomal Edema Growth after Primary Intracerebral Hemorrhage

Primary analysis: Fibrosis-4 score, continuous
	Beta	95% Confidence Interval	P value
Unadjusted	0.03	−0.01 – 0.12	0.48
Model 2	0.07	−0.01 – 0.18	0.10
Model 3	0.04	−0.04 – 0.12	0.36
Model 4	0.04	−0.03 – 0.13	0.26
Secondary analysis: High Fibrosis-4 versus Low Fibrosis-4†
	Beta	95% Confidence Interval	P value
Unadjusted	0.03	−0.46 – 0.39	0.88
Model 2	0.24	−0.25 – 0.73	0.34
Model 3	0.07	−0.36 – 0.50	0.75
Model 4	0.12	−0.32 – 0.55	0.60

^*Multiple linear regression was used to model the association between the Fibrosis-4 score and absolute 96-hour perihematomal edema (PHE) growth, which was defined as: absolute difference between 96-hour PHE volume and admission PHE volume. Model 2 was adjusted for age, sex, and race. Model 3 was additionally adjusted for serum sodium, antiplatelet use, and admission hematoma volume. Model 4 was additionally adjusted for intracerebral hemorrhage location (lobar versus deep versus infratentorial). PHE growth was log transformed.

^†Patients with a high Fibrosis-4 score (>3.25) were compared to patients with a low Fibrosis-4 score (<1.45).