Table 3:
Baseline characteristics of participants included in eGFR analysis (study A and B combined)
| Characteristic | Total (n= 671) | Serum uric acid (mg/dL) | P value | ||
|---|---|---|---|---|---|
| Low (≤ 5.7) (n= 230) | Medium (5.71-7.39) (n= 214) | High (≥7.4) (n= 227) | |||
| Age (years), mean (std) | 45 (10) | 44 (10) | 45 (10) | 47 (10) | < 0.01 |
| White, n (%) | 635 (95) | 218 (95) | 205 (96) | 212 (93) | 0.53 |
| Male, n (%) | 333 (50) | 54 (23) | 119 (56) | 160 (70) | < 0.001 |
| BMI (kg/m2), mean (std) | 27.6 (5.0) | 26.2 (4.8) | 27.4 (4.6) | 29.1 (5.1) | < 0.001 |
| SUA (mg/dL), mean (std) | 6.7 (2.0) | 4.6 (0.8) | 6.5 (0.4) | 9.0 (1.4) | < 0.001 |
| SBP, mean (std) | 116 (12) | 115 (12) | 117 (12) | 117 (13) | 0.10 |
| DBP, mean (std) | 74 (9) | 74 (10) | 74 (9) | 75 (9) | 0.56 |
| eGFR (mL/min/1.73 m2), mean (std) | 63 (28) | 78 (26) | 62 (27) | 50 (23) | < 0.001 |
| Ualbum (mg/24 hours), median (IQR) | 17 (8-39) | 15 (7-29) | 16 (8-37) | 23 (10-62) | < 0.001 |
| GenoType | 0.04 | ||||
| PKD1-T, n (%) | 335 (50) | 112 (49) | 108 (51) | 115 (51) | |
| PKD1-NT, n (%) | 181 (27) | 48 (21) | 65 (30) | 68 (30) | |
| PKD2, n (%) | 111 (17) | 49 (21) | 30 (14) | 32 (14) | |
| NMD, n (%) | 44 (7) | 21 (9) | 11 (5) | 12 (5) | |
| Treatment, n (%) | 339 (51) | 113 (49) | 110 (51) | 116 (51) | 0.87 |
| Current smoking, n (%) | 51 (8) | 14 (6) | 16 (7) | 21 (9) | 0.44 |
| Diuretic use, n (%) | 94 (14) | 24 (10) | 33 (15) | 37 (16) | 0.15 |
| Allopurinol use, n (%) | 39 (6) | 12 (5) | 9 (4) | 18 (8) | 0.22 |
BMI: body mass index; DBP: diastolic blood pressure; eGFR: estimated GFR using the CKD-EPI equation; IQR: interquartile range; NMD: no mutation detected; PKD1-T: truncating PKD1 mutation; PKD1-NT: nontruncating PKD1 mutation; PKD2: PKD2 mutation; SBP: systolic blood pressure; std: standard deviation; SUA: serum uric acid; treatment: randomized to lisinopril + telmisartan; Ualbum: urinary albumin excretion.
The P values are based on analysis of variance (ANOVA) for continuous variables and the Chi-square test for categorical variables. For Ualbum the log value was used.