Table 4:
Baseline characteristics of Study B participants included in event analysis
| Characteristic | Total (n= 316) | Serum uric acid (mg/dL) | P value | ||
|---|---|---|---|---|---|
| Low (≤ 6.4) (n= 111) | Medium (6.41-7.99) (n= 95) | High (≥ 8.0) (n= 110) | |||
| Age (years), mean (std) | 51 (8) | 52 (7) | 51 (8) | 51 (8) | 0.34 |
| White, n (%) | 300 (95) | 110 (99) | 86 (91) | 104 (95) | 0.02 |
| Male, n (%) | 151 (48) | 27 (24) | 49 (52) | 75 (68) | < 0.001 |
| BMI (kg/m2), mean (std) | 27.9 (5.2) | 26.7 (4.9) | 28.3 (5.8) | 28.7 (4.7) | < 0.01 |
| SUA (mg/dL), mean (std) | 7.3 (1.9) | 5.4 (0.7) | 7.1 (0.5) | 9.3 (1.3) | < 0.001 |
| SBP (mmHg), mean (std) | 119 (11) | 119 (10) | 118 (11) | 120 (12) | 0.60 |
| DBP (mmHg), mean (std) | 75 (8) | 76 (9) | 74 (7) | 77 (9) | 0.02 |
| eGFR (mL/min/1.73 m2), mean (std) | 40 (13) | 46 (13) | 41 (13) | 35 (11) | < 0.001 |
| Years of follow-up, median (IQR) | 3.6 (2.5-4.7) | 4.0 (3.1-5.1) | 3.7 (2.3-4.6) | 3.1 (1.9-4.2) | < 0.001 |
| Ualbum (mg/24 hours, median (IQR) | 25 (11-62) | 22 (10-47) | 22 (9-62) | 39 (12-82) | 0.02 |
| GenoType | 0.92 | ||||
| PKD1-T, n (%) | 171 (54) | 59 (53) | 54 (57) | 58 (53) | |
| PKD1-NT, n (%) | 83 (26) | 27 (24) | 26 (27) | 30 (27) | |
| PKD2, n (%) | 47 (15) | 18 (16) | 12 (13) | 17 (15) | |
| NMD, n (%) | 15 (5) | 7 (6) | 3 (3) | 5 (5) | |
| Treatment, n (%) | 156 (49) | 51 (46) | 57 (60) | 48 (44) | 0.04 |
| Current smoking, n (%) | 19 (6) | 8 (7) | 5 (5) | 6 (5) | 0.80 |
| Diuretic use, n (%) | 61 (19) | 18 (16) | 19 (20) | 24 (22) | 0.56 |
| Allopurinol use, n (%) | 28 (9) | 9 (8) | 8 (8) | 11 (10) | 0.87 |
BMI: body mass index; DBP: diastolic blood pressure; eGFR: estimated GFR using the CKD-EPI equation; IQR: interquartile range; NMD: no mutation detected; PKD1-T: truncating PKD1 mutation; PKD1-NT: nontruncating PKD1 mutation; PKD2: PKD2 mutation; SBP: systolic blood pressure; std: standard deviation; SUA: serum uric acid; treatment: randomized to lisinopril + telmisartan; Ualbum: urinary albumin excretion.
The P values are based on analysis of variance (ANOVA) for continuous variables and the Chi-square test for categorical variables. For Ualbum the log value was used.
The rank sum test was used to compare years of follow-up between groups.