Table 5:

Association of serum uric acid level with outcomes in Study B (Hazard ratio, 95% confidence intervals)

Model	Serum uric acid categorized by tertiles
	Low (≤ 6.4 mg/dL)	Medium (6.41-7.99 mg/dL)	High (≥ 8.0 mg/dL)
1	1.0 (ref)	1.7 (1.1-2.6)	2.9 (2.0-4.3)
2	1.0 (ref)	1.8 (1.1-2.8)	2.9 (1.9-4.4)
3	1.0 (ref)	1.8 (1.1-2.8)	2.9 (1.9-4.4)
4	1.0 (ref)	1.3 (0.8-2.0)	1.1 (0.7-1.8)

Outcomes (events): 50% decrease in eGFR, ESKD or death

Ref: reference group

Model 1: unadjusted.

Model 2: adjusted for age, sex, race, body mass index, PKD genotype, treatment group (lisinopril + telmisartan/lisinopril + placebo), systolic blood pressure, diastolic blood pressure, 24-hour urine albumin excretion, and current smoking (month 24).

Model 3: further adjusted for diuretic use and allopurinol use at month 24.

Model 4: further adjusted for eGFR at month 24.