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. 2021 Feb 11;16:1021–1036. doi: 10.2147/IJN.S283406

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© 2021 Hu et al.

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Hierarchical micro/nanoscale topography-induced actin cytoskeleton polymerization is required for TAZ activation. (A) Immunofluorescence staining for TAZ in Cytochalasin D treated PDLSCs cultured on Ti, SLA and SLM-AHT titanium surfaces after 3 days osteoinduction (green, TAZ; blue, DAPI). (B) The statistical analysis of the percentage of nuclear TAZ intensity against total TAZ intensity of (A). (C) The relative mRNA levels of TAZ target genes Cyr61 and CTGF in cytochalasin D treated PDLSCs on different titanium surfaces after 3 days osteoinduction. Error bars represent SD (n = 3). **P <0.01.