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. 2021 Feb 11;16:1021–1036. doi: 10.2147/IJN.S283406

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© 2021 Hu et al.

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Hierarchical micro/nanoscale topography activating MAPK signaling pathways is essential for TAZ activation. (A) The protein expression levels of MAPK signaling pathways molecules by Western blot after 3 days osteoinduction on Ti, SLA and SLM-AHT surfaces. (B) (Left panel) Immunofluorescence staining for TAZ in U0126 or SB203580-treated PDLSCs cultured on Ti, SLA and SLM-AHT titanium surfaces after 3 days osteoinduction (green, TAZ; blue, DAPI). (Right panel) The statistical analysis of the percentage of nuclear TAZ intensity against total TAZ intensity. (C) The relative mRNA levels of TAZ target genes Cyr61 and CTGF in U0126 or SB203580-treated PDLSCs on different titanium surfaces after 3 days osteoinduction. Error bars represent SD (n = 3). **P <0.01.