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. 2021 Feb 11;16:1021–1036. doi: 10.2147/IJN.S283406

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© 2021 Hu et al.

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Schematic representation of the role and activation mechanism of TAZ in hierarchical microgroove/nanopore topography regulating stem cell differentiation. Hierarchal microgroove/nanopore topography could promote the polymerization of actin cytoskeleton and activation of ERK and p38 MAPK signaling pathway, which were essential for TAZ activation. Enhanced transcriptional activity and nuclear localization of TAZ could accelerate osteogenesis and impair adipogenesis.