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. 2021 Feb 16;12:1063. doi: 10.1038/s41467-021-21221-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — The linear regression graph plots the % inhibition of the parasite liver burden load, normalized across the two mAb panels, against: a Fab apparent affinity as the dissociation constant (K_d) measured to the NPNA₆ peptide using isothermal titration calorimetry; (b) K_d, (c) association rate constant (k_on), and (d) dissociation rate constant (k_off) measured against rsCSP using bio-layer interferometry. The dashed line indicates the fitted linear regression model with 95% confidence interval shaded in grey. The R² value for each model is displayed, together with the average R² from 1000 models from bootstrapping (R²-boot). Data points for each mAb are colored as shown. Source data are provided as a Source Data file.