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. 2021 Feb 16;11:3876. doi: 10.1038/s41598-021-83496-3

Figure 2.

Figure 2

89Zr-anti-CD44 pharmacokinetics and biodistribution in mice, and CD44 expression on leukocytes from mouse spleen. (A) 89Zr-anti-CD44 pharmacokinetics in normal Balb/c mice (n = 5) and biodistribution in SNU-C5 tumor-bearing Balb/c nude mice (n = 4) after intravenous injection. Data are mean ± S.D. of % ID/g. (B) CD44 and CD11b expression on leukocytes isolated from the spleen of a normal Balb/c mouse. Single-cell suspensions were obtained by mincing the spleen. Representative flow cytometry forward and side scatter analysis plots (left) demonstrate the R1 region that corresponds to lymphocytes and R2 region that corresponds to myeloid cells. Flow cytometry with FITC-anti-CD44 and APC-anti-CD11b (right) reveal that cells of the R2 region are CD11b + /CD44 + .