Fig. 3. Cross-frequency similarity of the estimated functional interactions.

a Normalized weights of pairwise MEM interaction matrices, J_ij, estimated from the lowest (i.e., θ) and highest (i.e., high γ) frequency bands for a representative patient (#5). Edges from the interaction matrices with corresponding direct anatomical connections are marked by ‘o’ and their size indicates the number of estimated streamlines between each pair of regions. The functional edges without any detected anatomical connections are marked by ‘.’. Edges are color-coded based on the pairwise Euclidean distance between recorded brain regions. Red line represents the linear fit to the scatter plots (slope = 0.51 and intercept = 0.02 in panel a, slope = 0.61 and intercept = 0.28 in panel b) and each dashed red lines represent the 95% confidence interval. b Co-activation rates calculated from the same patient’s binarized band-passed power amplitude states at the lowest (i.e., θ) and highest (i.e., high γ) frequency bands.