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. 2021 Feb 16;4:210. doi: 10.1038/s42003-021-01700-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — The detection accuracy (measure via AUC) of structural connectivity between brain regions using several functional connectivity estimation methods, or a representative patient (#5) using three recording montages -- referential (a), local multiple linear regression (c), and global mean signal regression (e) montages. b, d, f The structure-function coupling, measured as the correlation between structural and functional connectivity weights of sampled brain regions for the same patient and three recording montages. Functional connectivity estimates based on the pairwise MEM and co-activation rates were calculated from binarized (‘0’ and ‘1’) power amplitude states. The remaining functional connectivity estimates (Pearson correlation, partial correlation, PLV, and WPLI) were derived from the band-passed iEEG and band-passed iEEG power time series. The results for different frequency bands are color-coded based on the legend in panel e. The AUC and correlation values significantly higher than those of geometric structural nulls (one-sided permutation test, n = 10, 000, p < 0.05) are depicted as ‘X’, and values significant after FDR correction for multiple comparisons across frequency bands are depicted as ‘O’.