Figure 1.

Atherosclerosis development in Ldlr^−/− mice lacking Abcc6. Atherosclerotic plaque deposition in aorta was assessed by measuring the en face surface area stained by Oil Red O staining. Littermate mice were maintained on an atherogenic diet (high fat diet) or regular chow for 16 weeks. (A) Quantification of aortic lesions is shown as percentage of the aorta surface. (B) Representative images of the Oil Red O staining. Results are shown as means ± SEM. p-values were determined by one-way ANOVA and Tukey’s post hoc test. *p < 0.05, **p < 0.01, ****p < 0.0001.