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. 2021 Feb 16;11:3881. doi: 10.1038/s41598-021-82966-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of genes related to cholesterol and extracellular purine metabolisms and cytokines/chemokines in macrophages and foam cells derived from Abcc6^−/−;Ldlr^−/− and control Ldlr^−/− mice. Real-time RT-PCRs were performed using TaqMan probes specific for Enpp1 (A), Nt5e (B), Ccl-2 (C), Ccr-2 (D) and TNF-α (E) cDNAs. Units are the relative gene expression normalized to Hmbs. The most consistent changes and probably the most physiologically relevant are shown in panels (B,C) with Nt5 and Ccl-2 expression significantly increased in cells lacking Abcc6. Data points represent individual mice from which bone marrow-derived macrophages were isolated and used for experiments. Results are shown as means ± SEM. p-values were determined by Student’s t-test, *p < 0.05.