Table 1.

Lipoprotein profile analysis of mouse models and human subjects lacking ABCC6.

Diets	Genotype		Total	LDL	HDL	Triglycerides
	Ldlr	Abcc6	Cholesterol
			mg/dL	mg/dL	mg/dL	mg/dL
High fat	−/−	+/+	1354 ± 92.8	534.6 ± 37.1	241.2 ± 33.2	74.47 ± 15.1
High fat	−/−	+/-	1175 ± 84.3	811.2 ± 56.2**	134.3 ± 31.3*	64.51 ± 10.2
High fat	−/−	−/−	1318 ± 47.3	900.3 ± 49.6***	101.8 ± 8.2**	67.54 ± 9.26
Chow	−/−	+/+	234.8 ± 35.4	158.0 ± 33.0	59.8 ± 5.4	6.12 ± 2.3
Chow	−/−	+/-	310.7 ± 25.9	130.0 ± 17.9	56.6 ± 12.2	11.74 ± 2.8**
Chow	−/−	−/−	255.0 ± 26.9	165.8 ± 14.9	70.2 ± 12.8	26.31 ± 3.5***
High fat	+/+	+/+	168.8 ± 18.0	37.6 ± 8.8	115.8 ± 5.3	3.52 ± 0.25
High fat	+/+	−/−	121.7 ± 3.5**	42.5 ± 3.5	68.6 ± 4.2####	5.97 ± 1.34*
Chow	+/+	+/+	131.7 ± 9.6	25.7 ± 5.4	101.0 ± 10.7	2.24 ± 0.21
Chow	+/+	−/−	125.4 ± 4.6	41.6 ± 1.6**	76.2 ± 4.6#	3.61 ± 0.89*
Healthy controls			204.6 ± 12.3	121.6 ± 8.2	68.5 ± 5.1	85.22 ± 8.4
PXE patients			188.6 ± 7.6	113.0 ± 5.8	50.5 ± 2.2###	102.2 ± 8.9

Bold shows significant differences with controls.

Mice age: 5 months-old, n = 3 to 8.

Humans: Age- and sex-matched: PXE: 45.2 ± 2.5 years; Controls: 45.3 ± 2.7 years, Ctrl = 14, PXE = 32.

p-values were determined by one-way ANOVA and Tukey’s post hoc test (*) or Student’s t-test (#).

*, ^# p < 0.05, **, ^## p < 0.01, ***, ^### p < 0.001 ****, ^#### p < 0.0001.