Table 4.
Genetic analysis of the HN gene of Thai CPIV-5 and reference PIV-5 at the human-specific residues.
| Virus | Host | Location | Primate specific amino acid | Lineage specific amino acida | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 22 | 49 | 57 | 254 | 318 | 460 | 536 | 19 | 43 | 62 | 141 | 252 | 353 | 446 | |||
| Reference PIV-5 | ||||||||||||||||
| AGS | AGS Cell | L | S | G | A | S | T | T | T | K | T | T | F | F | G | |
| DEN | Human | UK | L | S | G | A | S | T | T | T | K | T | T | F | F | G |
| MIL | Human | UK | L | S | G | A | S | T | T | T | K | T | T | F | F | G |
| MEL | Human | UK | L | S | G | A | S | T | T | T | K | T | T | F | F | G |
| RQ | Human | UK | L | S | G | A | S | T | T | T | K | T | T | F | F | G |
| LN | Human | UK | L | S | G | A | S | T | T | T | K | T | T | F | F | G |
| W3A | Macaque cell | I | A | R | A | N | T | M | T | K | T | T | F | F | G | |
| SER | Swine | Germany | I | A | R | T | N | K | M | T | K | T | T | F | F | G |
| KNU-11 | Swine | South Korea | I | A | R | T | N | K | M | T | K | T | T | F | F | G |
| PV5-BC14 | Calve | China | I | A | R | T | N | K | M | T | K | T | T | F | F | G |
| ZJQ-221 | Lesser panda | China | I | A | R | T | N | K | M | T | K | T | T | F | F | G |
| CAN | Pangolin | China | I | A | R | T | N | K | M | T | K | T | T | F | F | G |
| H221 | Canine | UK | I | A | R | T | N | K | I | T | K | T | T | F | F | G |
| 78524 | Canine | UK | I | A | R | T | N | K | M | T | K | T | T | F | F | G |
| CPI + | Canine | USA | I | A | R | T | N | K | M | T | K | T | T | L | F | G |
| CPI- | Canine | USA | I | A | R | T | N | K | M | T | K | T | T | L | F | G |
| 08-1990 | Canine | South Korea | I | A | R | T | N | K | M | I | E | I | A | L | L | R |
| D277 | Canine | South Korea | I | A | R | T | N | K | M | I | E | I | A | L | L | R |
| 1168-1 | Canine | South Korea | I | A | R | T | N | K | M | T | K | T | T | F | F | G |
| CC-14 | Canine | China | I | A | R | T | N | K | I | T | K | T | T | F | F | G |
| HeN0718 | Canine | China | I | A | R | T | N | K | M | I | E | I | A | L | L | R |
| This study | ||||||||||||||||
| CU-D58 | Canine | Thailand | I | A | R | T | N | K | M | I | E | I | A | L | L | R |
| CU-D103 | Canine | Thailand | I | A | R | T | N | K | M | I | E | I | A | L | L | R |
| CU-D133 | Canine | Thailand | I | A | R | T | N | K | I | I | E | I | A | L | L | R |
| CU-D151 | Canine | Thailand | I | A | R | T | N | K | M | I | E | I | A | L | L | R |
| CU-D373 | Canine | Thailand | I | A | R | T | N | K | M | I | E | I | A | L | L | R |
| CU-D376 | Canine | Thailand | I | A | R | T | N | K | M | I | E | I | A | L | L | R |
| CU-D381 | Canine | Thailand | I | A | R | T | N | K | M | I | E | I | A | L | L | R |
| CU-D399 | Canine | Thailand | I | A | R | T | N | K | M | T | K | T | I | F | F | G |
| CU-D400 | Canine | Thailand | I | A | R | T | N | K | M | I | E | I | A | L | L | R |
| CU-D406 | Canine | Thailand | I | A | R | T | N | K | M | I | E | I | A | L | L | R |
| CU-D466 | Canine | Thailand | I | A | R | T | N | K | M | I | E | I | A | L | L | R |
| CU-D585 | Canine | Thailand | I | A | R | T | N | K | M | I | E | I | A | L | L | R |
| CU-D20804 | Canine | Thailand | I | A | R | T | N | K | M | I | E | I | A | L | L | R |
aLineage: CPIV-5 sublineage; Thai, Chinese, and Korean sublineages.