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. 2021 Feb 16;11:3908. doi: 10.1038/s41598-021-82343-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The expression pattern of 7 CATH1 homologous genes with the top 30 highest GS values to the DJ3-lab and their top 30 related genes in the pink module. (A) The expression (FPKM) of 42 genes in the pink module include 7 CATH1 homologous genes with the top 30 highest GS values to the DJ3-lab and their top 30 related genes. Genes are clustered by their expression pattern. The 15 genes associated with lipid metabolism or autophagy are framed in red. (B) Comparison of the relative transcript abundances of the 15 lipid metabolism- or autophagy-associated genes from different PWN stages (normalized by J2) by FPKM. (C) Comparison of the relative transcript abundances of the 15 lipid metabolism- or autophagy-associated genes from different PWN stages (normalized by J2) by RT-PCR. (D) Heatmap and clustering analysis of the results from (B). (E) Heatmap and clustering analysis of the results from (C). Genes in the black box are associated with autophagy, while those in the khaki box are associated with lipid metabolism.