Table 1.

Diagnostic considerations for ICI-induced myocarditis and cardiotoxic events.

1. Assessment of risk factors	Prior cardiovascular events and risk factors for atherosclerotic coronary artery disease
2. Biomarker analysis	• Baseline and serial cardiac troponin I • B-type natriuretic peptide
3. Diagnostic testing and imaging	• Electrocardiogram for abnormal PR, QRS and QTc intervals, and evidence of atrial and ventricular arrhythmias • Echocardiogram to assess cardiac function and myocardial wall motion • Cardiac MRI for increased T2-signal intensity, and abnormal early and late gadolinium signal intensity in contrast-enhanced MRI • Tagged cine MRI for strain analysis
4. Endomyocardial biopsy	• Tissue edema • Lymphocyte and macrophage infiltration