Table 2.
Effect of the metabolic inhibitor drug on various virus infected cell line.
| Virus | Nucleic acid | Metabolism targeted | Drug used | Cell line | Outcome | Reference |
|---|---|---|---|---|---|---|
| KSHV | DNA | Fatty acid synthesis | TOFA | Tert-immortalized microvascular endothelial (TIME) cells | Decrease the production of virion | (154) |
| Marek’s disease virus | C75 and TOFA | Chicken embryonic fibroblast 396 cells (CEFs) |
Reduce virus replication | (155) | ||
| Vaccinia virus | TOFA and C75 | BSC40 cells | Reduction in virus | (156) | ||
| HCMV | TOFA and C75 | Fibroblasts/MDCK cells | Reduce viral replication | (10) | ||
| Chikungunya virus | RNA | C75 and cerulenin | HeLa cells | Decrease the replication of virus | (157) | |
| HIV | Fasnall and C75 | TZM-bl cells | Inhibit viral replication | (42) | ||
| WNV | C75 and cerulenin | Huh-7 cells and vero cell | Decrease the production of virus | (158) | ||
| Usutu virus | TOFA | Huh-7, vero and Neuro2a cell | (159) | |||
| DENV | C75 and cerulenin | Huh-7.5 cells | Reduction in DENV replication in dose dependent manner | (22) | ||
| Influenza A | TOFA and C75 | Fibroblasts/MDCK cells | Reduce viral replication | (10) | ||
| Hepatitis C virus | C75 | Huh7 and Huh7.5.1 cells | (21) | |||
| DENV | RNA | Fatty acid oxidation | Etomoxir | Huh-7 cells | Decrease in virus in dose dependent manner | (160) |
| Vaccinia virus | DNA | BSC40 cells | Reduction in virus | (156) | ||
| H1NI influenza A virus | RNA | Glycolysis inhibition | 2DG and 3-BrPa | MDCK cells | Decrease viral replication in dose dependent manner | (161) |
| DENV | 2DG and Oxamate | human foreskin fibroblasts | Reduce DENV replication | (15) | ||
| Human retrovirus HTLV-1 | 2DG | PBMCs | Inhibition of transcription of HTLV-1 | (162) | ||
| Rhinoviruses | Hela cell, fibroblast | Inhibit viral replication | (163) | |||
| KSHV | DNA | Oxamate | TIME and iSLK cells | Reduce viral production | (154) | |
| HSV-1 | DNA | Glutamine inhibition | L-DON | Vero cells | Anti-viral effect | (164) |
| VSV | RNA | Vero, LLCMK2, BHK and primary monkey kidney cells | (165) | |||
| Human parainfluenza virus type 2 | ||||||
| Mumps viruses | ||||||
| Human respiratory syncytial virus | CV-1 cells | (166) |
TOFA, 5-(tetradecyloxy)-2-furoic acid; 3-BrPa, 3-bromopyruvate; MDCK cells, Madin-Darby canine kidney cells; PMBCs, peripheral blood mononuclear cell; 2DG, 2-deoxy-D-glucose; L-DON, 6-diazo-5-oxo-L-norleucine; LLCMK2, rhesus monkey kidney epithelial cells; BHK, baby hamster kidney fibroblasts; CV-1 cells, normal African green monkey kidney fibroblast cells.