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Endocannabinoid signaling in neural and microglial circuits. Retrograde neuronal endocannabinoid signaling refers to the process of the release and the travel of endocannabinoids backward from the postsynaptic neuron to bind to the CB1 receptors on the axon terminal of a presynaptic neuron. Microglial cells communicate via release of endocannabinoid into the extracellular space, which bind to the CB2 receptors on microglia cell membranes.
