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. 2021 Feb 3;14:606808. doi: 10.3389/fnins.2020.606808

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Copyright © 2021 Carrera, Tomberlin, Kurtz, Karakaya, Bostanciklioglu and Albayram.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reciprocal interactions between microglia and presynaptic GABAergic neuron. (A) Old WT mouse brain: Normal neuronal-glial communication prevents microglial reactivation through endocannabinoid signaling between CB1 expressed GABAergic neurons and microglia. (B) Old GABA-CB1KO mouse brain: Disrupted endocannabinoid signaling between CB1 expressed GABAergic neurons and microglia break down control of microglial reactivation and thus, exacerbating age-dependent neuro-inflammation in the brain.