Table 1.
Summary of the significantly altered cytokines in tumor cells and fibroblasts following NLRP3 modulation (compared to untreated controls) (p < 0.05, full data available in Supplementary Table 4 ).
| VX765 | LPS | Nigericin | LPS& Nigericin | |
|---|---|---|---|---|
| A549 | ↓CXCL1 | ↓CXCL1, IL6, CXCL8, CCL13, CCL22 | ||
| ↑GMCSF | ↑MIF | ↑GMCSF, MIF | ||
| MCF | – | ↑CCL23 | ↑CXCL8, CCL13 | ↑CCL21, CCL27, CXCL5, CCL11, CCL26, CXCL6, GMCSF, CXCL1, CXCL2, CCL1, IFNg, IL4, CXCL8, IL10, CCL8, CCL7, CCL13, CXCL9, CCL20, CCL23, CCL25 |
| PC3 | – | – | ↑MIF | ↑CCL21, CCL11, GMCSF, CCL1, IL4, CCL8, CCL22, CXCL9, CCL3, CCL23, CCL17, TNFa |
| SH-SY5Y | ↑CCL11, CCL26 | ↑CCL21, CCL11, CCL24, CCL22, TNFa | ↑MIF | ↑CXCL5, CCL24, IL2, CCL7, CCL22, CCL3, TNFa |
| U138MG | – | – | ↑MIF | ↑MIF |
| Fibroblasts | – | ↑CCL21, CXCL13, CCL27, CXCL5, CCL11, CCL24, CCL26, GMCSF, CXCL1, CXCL2, CCL1, IL2, IL4, IL6, CXCL8, IL10, IL16, CXCL10, CXCL11, CCL2, CCL8, CCL7, CCL22, CXCL9, CCL5, CCL20, CCL19, CCL23, CXCL16, CXCL12, CCL17, CCL25 | ↑MIF | – |