TABLE 3.
Common hub mRNAs of WGCNA and PPI analysis in the yellow and blue modules.
| Gene description | WGCNA |
PPI analysis | Limma analysis |
|||||||
| Module | GS | GS P-value | MM | MM P-value | K Score | Log2FC | FDR | Up or Down | ||
| ADCY6 | Adenylate cyclase 6 | Yellow | −0.88914374 | 2.10176E-05 | 0.977029022 | 2.01881E-09 | Cluster 1: 59.864 | −4.32322549 | 1.62E-13 | Down |
| FSTL3 | Follistatin like 3 | Yellow | −0.86138354 | 7.54665E-05 | 0.975307638 | 3.10296E-09 | Cluster 2: 27.167 | −6.06007779 | 1.09E-12 | Down |
| ADCY1 | Adenylate cyclase 1 | Blue | 0.815437991 | 0.000378522 | 0.888705991 | 2.14994E-05 | Cluster 1: 59.864 | 4.540162745 | 8.07E-12 | Up |
| CASR | Calcium sensing receptor | Blue | 0.889887433 | 2.02E-05 | 0.851114402 | 0.000113203 | Cluster 1: 59.865 | 4.154828687 | 0.000000007 | Up |
| CCKAR | Cholecystokinin A receptor | Blue | 0.85841125 | 8.51358E-05 | 0.892040065 | 1.80473E-05 | Cluster 2: 27.170 | 5.33799687 | 3.77E-12 | Up |
| CFTR | CF transmembrane conductance regulator | Blue | 0.877568366 | 3.71619E-05 | 0.916502067 | 4.07889E-06 | Cluster 3: 15.467 | 6.435926076 | 1.21E-13 | Up |
| CRH | Corticotropin releasing hormone | Blue | 0.850563948 | 0.000115593 | 0.930216776 | 1.43E-06 | Cluster 2: 27.172 | 4.785431728 | 1.38E-11 | Up |
| ENAM | Enamelin | Blue | 0.900736051 | 1.11178E-05 | 0.941971756 | 4.86E-07 | Cluster 3: 15.467 | 4.953118924 | 2.71E-12 | Up |
| GLP1R | Glucagon-like peptide 1 receptor | Blue | 0.850921895 | 0.000114034 | 0.866580845 | 6.07E-05 | Cluster 2: 27.172 | 6.07312786 | 4.19E-13 | Up |
| GLRA1 | Glycine receptor alpha 1 | Blue | 0.839537197 | 0.000172792 | 0.878336963 | 3.58E-05 | Cluster 3: 15.467 | 4.287442801 | 2.79E-11 | Up |
| GPR55 | G protein-coupled receptor 55 | Blue | 0.855998273 | 9.37062E-05 | 0.909933263 | 6.33E-06 | Cluster 1: 59.864 | 4.930381688 | 9.49E-12 | Up |
| GPRC6A | G protein-coupled receptor class C group 6 member A | Blue | 0.832428091 | 0.000220505 | 0.918722191 | 3.49E-06 | Cluster 2: 27.167 | 4.303509957 | 4.51E-12 | Up |
| HCRTR2 | Hypocretin receptor 2 | Blue | 0.836214917 | 0.00019392 | 0.915205528 | 4.46E-06 | Cluster 2: 27.167 | 4.558044205 | 2.09E-11 | Up |
| HTR5A | 5-Hydroxytryptamine receptor 5A | Blue | 0.874246266 | 4.33124E-05 | 0.952672218 | 1.46E-07 | Cluster 1: 59.864 | 4.038237249 | 9.38E-12 | Up |
| KRT2 | Keratin 2 | Blue | 0.880981394 | 3.16052E-05 | 0.956618535 | 8.76E-08 | Cluster 3: 15.467 | 4.448300733 | 4.48E-11 | Up |
| LCE1E | Late cornified envelope 1E | Blue | 0.866279363 | 6.1499E-05 | 0.957508323 | 7.75E-08 | Cluster 3: 15.467 | 4.542418549 | 2.47E-11 | Up |
| TAAR1 | Trace amine associated receptor 1 | Blue | 0.839448887 | 0.000173328 | 0.947895963 | 2.58E-07 | Cluster 2: 27.167 | 4.62537402 | 4.84E-13 | Up |
| TAS2R3 | Taste 2 receptor member 3 | Blue | 0.878360965 | 3.58053E-05 | 0.939606798 | 6.15E-07 | Cluster 1: 59.864 | 4.106640312 | 5.95E-12 | Up |
| TAS2R41 | Taste 2 receptor member 41 | Blue | 0.905530556 | 8.34943E-06 | 0.887652146 | 2.27E-05 | Cluster 1: 59.865 | 4.606795778 | 1.14E-11 | Up |
| VSTM2B | V-set and transmembrane domain containing 2B | Blue | 0.801793908 | 0.000562628 | 0.867303193 | 5.89E-05 | Cluster 4: 12.121 | 5.226197818 | 4.11E-12 | Up |
WGCNA, weight gene co-expression network analysis; PPI, protein–protein interaction; GS, gene significance; MM, module membership; log2FC, log2 (fold-change) values of differentially expressed genes between fertile and infertile women with endometriosis.