Figure 1.

CSF delivery of scAAV9.CB.CLN6 prevents classic autofluorescent storage material accumulation in several visual processing centers of the brain in Cln6^nclf mice

(A–C) A single, postnatal day 1 injection of scAAV9.CB.CLN6 delivered via CSF prevents storage material accumulation (ASM, green) in the (A) dorsal lateral geniculate (DLG), (B) primary visual cortex (V1), and (C) superior colliculus (SC) until 9 months of age. n = 6/treatment for each time point, represented by equal numbers of males and females. Mean ± SEM, one-way ANOVA for each time point, Bonferroni correction. ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.