Table 4.
Multivariable Cox regression hazard analysis for risk of the composite end point
| Univariable | Multivariable | |||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| V-FMR/A-FMR | 1.762 (1.250 to 2.438) | <0.001 | 1.654 (1.027 to 2.664) | 0.038 |
| Age, 1 year | 1.015 (1.005 to 1.026) | 0.004 | 1.027 (1.015 to 1.040) | <0.001 |
| Male sex | 1.255 (0.953 to 1.654) | 0.11 | ||
| NYHA functional class III/IV | 1.394 (1.016 to 1.912) | 0.039 | ||
| Atrial fibrillation | 1.161 (0.888 to 1.517) | 0.28 | 1.437 (1.046 to 1.973) | 0.025 |
| Systolic blood pressure, 1 mm Hg | 0.992 (0.985 to 0.998) | 0.015 | ||
| Log B-type natriuretic peptide, 1 pg/mL | 1.453 (1.289 to 1.637) | <0.001 | 1.332 (1.162 to 1.526) | <0.001 |
| Estimated glomerular filtration rate, 1 mL/min/1.73 m2 | 0.985 (0.978 to 0.991) | <0.001 | ||
| LV end-systolic dimension, 1 mm | 1.014 (1.005 to 1.023) | 0.002 | 1.017 (1.002 to 1.031) | 0.025 |
| LV ejection fraction, 1% | 0.983 (0.974 to 0.992) | <0.001 | ||
| LA volume index, 1 mL/m2 | 1.004 (1.002 to 1.006) | <0.001 | 1.004 (1.002 to 1.007) | 0.001 |
| Tricuspid regurgitation | 1.012 (0.710 to 1.442) | 0.95 | ||
| MR regurgitant volume, 1 mL | 1.012 (0.998 to 1.026) | 0.10 | ||
LV ejection fraction were not adjusted for multivariable regressions because of collinearity (between LV end-systolic dimension and LV ejection fraction, R=−0.80).
A-FMR, atrial functional mitral regurgitation; LA, left atrium; LV, left ventricle; MR, mitral regurgitation; NYHA, New York Heart Association; V-FMR, ventricular functional mitral regurgitation.