Table 5.

Multivariable Cox regression hazard analysis for individual prognostic predictors of ventricular functional mitral regurgitation (V-FMR) and atrial functional mitral regurgitation (A-FMR)

	Univariable		Multivariable
	HR (95% CI)	P value	HR (95% CI)	P value
(A) V-FMR
Age, 1 year	1.019 (1.007 to 1.030)	0.001	1.024 (1.012 to 1.036)	<0.001
Male sex	1.175 (0.854 to 1.616)	0.32
NYHA functional class III/IV	1.173 (0.840 to 1.638)	0.35
Atrial fibrillation	1.468 (1.092 to 1.973)	0.011
Systolic blood pressure, 1 mm Hg	0.995 (0.988 to 1.002)	0.17	0.991 (0.983 to 0.999)	0.028
Log B-type natriuretic peptide, 1 pg/mL	1.361 (1.191 to 1.554)	<0.001	1.325 (1.154 to 1.523)	<0.001
Estimated glomerular filtration rate, 1 mL/min/1.73 m2	0.989 (0.982 to 0.995)	0.001
LV end-systolic dimension, 1 mm	1.004 (0.992 to 1.016)	0.54
LV ejection fraction, 1%	0.989 (0.975 to 1.003)	0.12
LA volume index, 1 mL/m2	1.005 (1.002 to 1.008)	<0.001	1.004 (1.001 to 1.007)	0.008
Tricuspid regurgitation	0.955 (0.579 to 1.574)	0.86
MR regurgitant volume, 1 mL	1.011 (0.996 to 1.028)	0.16
(B) A-FMR
Age, 1 year	1.057 (1.015 to 1.101)	0.008	1.056 (1.002 to 1.114)	0.043
Male sex	0.972 (0.512 to 1.846)	0.93
NYHA functional class III/IV	2.864 (0.688 to 7.993)	0.13
Atrial fibrillation	1.821 (0.561 to 5.907)	0.32
Systolic blood pressure, 1 mm Hg	0.993 (0.975 to 1.011)	0.44
Log B-type natriuretic peptide, 1 pg/mL	1.837 (1.234 to 2.735)	0.003
Estimated glomerular filtration rate, 1 mL/min/1.73 m2	0.963 (0.947 to 0.979)	<0.001	0.979 (0.961 to 0.997)	0.025
LV end-systolic dimension, 1 mm	1.057 (1.006 to 1.110)	0.027	1.082 (1.022 to 1.145)	0.007
LV ejection fraction, 1%	0.964 (0.922 to 1.008)	0.11
LA volume index, 1 mL/m2	1.006 (1.003 to 1.010)	<0.001	1.005 (1.001 to 1.008)	0.022
Tricuspid regurgitation	1.990 (1.067 to 3.709)	0.030	2.389 (1.185 to 4.816)	0.015
MR regurgitant volume, 1 mL	1.018 (0.985 to 1.053)	0.29

LA, left atrium; LV, left ventricle; MR, mitral regurgitation; NYHA, New York Heart Association.